Childhood Wilms tumor, relapsed more than 20 years after diagnosis
Keywords:
Wilms tumor, kidney neoplasms, drug therapy, combination, second look surgery, recurrenceAbstract
Wilms tumor represents the most common renal neoplasm in childhood; however, in adulthood, it is a rare condition, and the optimal management is unknown. Treatments are usually extrapolated from the multimodal approach used in the pediatric population.
We present the case of a 29-year-old female patient with a history of stage III right-sided Wilms tumor (favorable classification) at the age of 4, managed with surgery, chemotherapy, and radiotherapy. More than 20 years later, recurrent Wilms tumor was confirmed in the peritoneum and both ovaries and treated with ICE (ifosfamide, carboplatin, and etoposide) chemotherapy regimen, leading to severe toxicity but a good response. The patient underwent salvage surgery with complete resection. Eventually, she presented new relapses managed with chemotherapy.
Author Biographies
Alicia Quiroga-Echeverri, Oncología Clínica, Unidad de Cancerología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
1. Oncología Clínica, Unidad de Cancerología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Luis Gabriel González-Pérez, Oncología Clínica, Unidad de Cancerología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
1. Oncología Clínica, Unidad de Cancerología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Juan Fernando Arango-Arteaga, Oncología Clínica, Unidad de Cancerología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
1. Oncología Clínica, Unidad de Cancerología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Ana María Arango-Rivas , Medicina Interna, Clínica AUNA, Medellín, Colombia.
2. Medicina Interna, Clínica AUNA, Medellín, Colombia.
Gabriel Jaime Varela-Aguirre , Hospital Pablo Tobón Uribe, Medellín, Colombia.
3. Hospital Pablo Tobón Uribe, Medellín, Colombia.
4. Clínica Aurora, Medellín, Colombia.
5. Hospital San Vicente Fundación, Rionegro, Colombia.
References
Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, et al. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. NIH Pub. No. 99-4649 [Internet]. Bethesda, MD; 1999 [citado: 2023 jul 15]. Disponible en: https://seer.cancer.gov/archive/publications/childhood/childhood-monograph.pdf
Scott RH, Stiller CA, Walker L, Rahman N. Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour. J Med Genet. 2006;43(9):705-15. http://doi.org/10.1136/jmg.2006.041723
Wang J, Li M, Tang D, et al. Current treatment for Wilms tumor: COG and SIOP standards. World J Pediat Surg. 2019;2:e000038. https://doi.org/10.1136/wjps-2019-000038
Terenziani M, Spreafico F, Collini P, Piva L, Perotti D, Podda M, et al. Adult Wilms' tumor: A monoinstitutional experience and a review of the literature. Cancer. 2004;101(2):289-93. https://doi.org/10.1002/cncr.20387
Mullen EA, Chi YY, Hibbitts E, Anderson JR, Steacy KJ, Geller JI, et al. Impact of surveillance imaging modality on survival after recurrence in patients with favorable-histology Wilms tumor: A report from the Children's Oncology Group. J Clin Oncol. 2018;36(34):JCO1800076. https://doi.org/10.1200/JCO.18.00076
Niedzielska E, Bronowicki K, Pietras W, Sawicz-Birkowska K, Trybucka K, Rąpała M, et al. Clinical factors in relapses of Wilms' tumor--results for the Polish Pediatric Solid Tumors Study Group. Adv Clin Exp Med. 2014;23(6):925-31. https://doi.org/10.17219/acem/37340
Zdrojowy R, Sawicz-Birkowska K, Apoznański W, Patkowski D, Szydełko T, Pietras W, et al. Adult Wilms tumour. Int Urol Nephrol. 2011;43(3):691-6. https://doi.org/10.1007/s11255-010-9868-7
Segers H, van den Heuvel-Eibrink MM, Pritchard-Jones K, Coppes MJ, Aitchison M, Bergeron C, et al. SIOP-RTSG and the COG-Renal Tumour Committee. Management of adults with Wilms' tumor: recommendations based on international consensus. Expert Rev Anticancer Ther. 2011;11(7):1105-13. https://doi.org/10.1586/era.11.76
Kung FH, Desai SJ, Dickerman JD, Goorin AM, Harris MB, Inoue S, et al. Ifosfamide/carboplatin/etoposide (ICE) for recurrent malignant solid tumors of childhood: a Pediatric Oncology Group Phase I/II study. J Pediatr Hematol Oncol. 1995;17(3):265-9. https://doi.org/10.1097/00043426-199508000-00009
Treger TD, Chowdhury T, Pritchard-Jones K, Behjati S. The genetic changes of Wilms tumour. Nat Rev Nephrol. 2019;15(4):240-51. https://doi.org/10.1038/s41581-019-0112-0
Abu-Ghosh AM, Krailo MD, Goldman SC, Slack RS, Davenport V, Morris E, et al. Ifosfamide, carboplatin and etoposide in children with poor-risk relapsed Wilms' tumor: a Children's Cancer Group report. Ann Oncol. 2002;13(3):460-9. https://doi.org/10.1093/annonc/mdf028
Wang J, Zhang L, Guo L, Que Y, Zhang Y, Sun F, et al. Irinotecan plus doxorubicin hydrochloride liposomes for relapsed or refractory Wilms tumor. Front Oncol. 2021;11:721564. https://doi.org/10.3389/fonc.2021.721564
Sforza S, Palmieri VE, Raspollini MR, Roviello G, Mantovani A, Basso U, et al. Robotic approach with neoadjuvant chemotherapy in adult Wilms' tumor: A feasibility study report and a systematic review of the literature. Asian J Urol. 2023;10(2):128-36. https://doi.org/10.1016/j.ajur.2021.10.004
Spreafico F, Ferrari A, Mascarin M, Collini P, Morosi C, Biasoni D, et al. Wilms tumor, medulloblastoma, and rhabdomyosarcoma in adult patients: lessons learned from the pediatric experience. Cancer Metastasis Rev. 2019;38(4):683-94. https://doi.org/10.1007/s10555-019-09831-3
Reinhard H, Aliani S, Ruebe C, Stöckle M, Leuschner I, Graf N. Wilms' tumor in adults: results of the Society of Pediatric Oncology (SIOP) 93-01/Society for Pediatric Oncology and Hematology (GPOH) Study. J Clin Oncol. 2004;22(22):4500-6. https://doi.org/10.1200/JCO.2004.12.099
Hayes-Jordan A, Green H, Prieto V, Wolff JE. Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy. J Pediatr Surg. 2012;47(4):782-7. https://doi.org/10.1016/j.jpedsurg.2011.12.018
Dome JS, Liu T, Krasin M, Lott L, Shearer P, Daw NC, et al. Improved survival for patients with recurrent Wilms tumor: the experience at St. Jude Children's Research Hospital. J Pediatr Hematol Oncol. 2002;24(3):192-8. https://doi.org/10.1097/00043426-200203000-00007
Spreafico F, Dalissier A, Pötschger U, Locatelli F, Michon JM, Peters C, et al.; EBMT Paediatric Diseases Working Party. High dose chemotherapy and autologous hematopoietic cell transplantation for Wilms tumor: a study of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant. 2020;55(2):376-83. https://doi.org/10.1038/s41409-019-0661-7
Kremens B, Gruhn B, Klingebiel T, Hasan C, Laws HJ, Koscielniak E, et al. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. Bone Marrow Transplant. 2002;30(12):893-8. https://doi.org/10.1038/sj.bmt.1703771
Büyükpamukçu M, Köksal Y, Varan A, Atahan L, Cağlar M, Akyüz C, et al. Late recurrence in children with Wilms' tumor. Turk J Pediatr. 2007;49(2):226-30. PMID: 17907529.
Senetta R, Macrì L, Pacchioni D, Castellano I, Cassoni P, Bussolati G. Late recurrence of Wilms' tumour with exclusive skeletal muscle phenotype 23 years after primary diagnosis. Virchows Arch. 2007;450(1):115-8. https://doi.org/10.1007/s00428-006-0326-y
Park WY, Hong KT, Ahn HY, Choi JY, Kang HJ, Park SH, et al. Late recurrence of Wilms tumor after 17 years: A case report. J Pediatr Hematol Oncol. 2020;42(6):e488-90. https://doi.org/10.1097/MPH.0000000000001473
Mitry E, Ciccolallo L, Coleman MP, Gatta G, Pritchard-Jones K; EUROCARE Working Group. Incidence of and survival from Wilms' tumour in adults in Europe: data from the EUROCARE study. Eur J Cancer. 2006;42(14):2363-8. https://doi.org/10.1016/j.ejca.2006.04.009
Ha TC, Spreafico F, Graf N, Dallorso S, Dome JS, Malogolowkin M, et al. An international strategy to determine the role of high dose therapy in recurrent Wilms' tumour. Eur J Cancer. 2013;49(1):194-210. https://doi.org/10.1016/j.ejca.2012.07.010
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