Large cell lymphoma in children and adolescents of the Instituto Nacional de Cancerología E.S.E.: (Bogotá, D.C., Colombia): 1980-2001
Keywords:
Lymphoma, large cell, survival rate, child, adolescent, ColombiaAbstract
Objective: To characterize and establish the survival of pediatric patients with lymphoma treated at the National Cancer Institute of Colombia during the period 1980-2001.
Methods: Clinical records of nineteen patients were reviewed, diagnosis was confirmed by morphology, and immune-phenotype was established with CD20, CD30, CD43, CD45RB, CD45RO, CD68, CD3, ALK, tdt and S-100 antibodies. Associations were established by using Fischer’s exact test, Kaplan-Meier’s method for survival, and the log rank test to compare survival trends.
Results: Ten patients were girls; the age median was eleven years, with a range between three and sixteen years. Seven cases presented lymphoma at the neck, which was the most frequent localization. Nine patients were at stage I; the most frequent immune-phenotype was that of T cells, with eleven cases. Thirteen patients presented complete remission. After two years, event-free survival was 47.3%, diseasefree survival was 99.8%, and global survival 68%. After five years, event-free survival was 28,8%.
Conclusion: A bigger number of patients must be studied in order to establish more precise estimations concerning clinical features and survival.
Author Biographies
Iliana de los Reyes, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología E.S.E., Grupo Oncología Pediátrica, Bogotá, D.C., Colombia.
Teresa Martínez, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología E.S.E., Grupo Epidemiología Clínica, Bogotá, D.C., Colombia.
Martha Vizcaíno, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología E.S.E., Grupo Oncología Pediátrica, Bogotá, D.C., Colombia.
Carlos Moreno, Instituto Nacional de Cancerología
Especialista en Hematopatología, Instituto Nacional de Cancerología E.S.E., Bogotá, D.C., Colombia.
References
Perkins SI, Segal GH, Kjedsberg CR. Classification of non-Hodgkin's lymphomas in children. Seminaries in Diagnostic Pathology 1995;12:303-311.
Cairo MS, Perkins SL. Non-Hodgkin's lymphoma in children. In: Bast RC Jr, Kufe DW, Pollock RE, Weichselbau RR, Holland JF, Frei E III. editores. Cancer Medicine. London: B. C. Decker; 2000.p. 2162-2167.
Zutter MM, Hess JL. Guidelines for the diagnosis of leukemia or lymphoma in children. Am J Clin Pathol 1998; 109 (Supl l):9-22.
Magrath IT. Malignant non-Hodgkin's lymphomas in children. In: Pizzo PA, Poplack DG, editores. Principles and Practice of Pediatric Oncology. 4ed. ed. Philadelphia: Lippincott Williams and Wilkins; 2001.p.661-706.
Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML et al. A revised European-American classification of lymphoma neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84(5): 1361-1392.
https://doi.org/10.1182/blood.V84.5.1361.1361
Rosemberg SA, Berad CW, Brown BW, Burke J, Dorfman RF, Glatsein E et al. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas. Cancer 1982;49:2112-2135.
https://doi.org/10.1002/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2
Collins RD, Swerdlow SH. Pediatric Hematopathology. 1 ed. New York: Churchill Livingstone; 2001.p.202, 239, 240, 249-257.
Frizzera G, Krishman J. Neoplasms of the lymphoid system. In: Stocker JT, Askin FB, editores. Pathology of Solid Tumors in Children. 3rd ed. London: Chapman Hall Medical; 1998.p.129-144.
Mora J, Filippa DA, Thaler HT. Large cell non-Hodgkin's lymphoma of childhood. Cancer 2000; 88:186-197.
https://doi.org/10.1002/(SICI)1097-0142(20000101)88:1<186::AID-CNCR26>3.0.CO;2-5
Sandlund JT, Santana V, Abromo witch M, Riberiro R, Mahmoud H, Ayers GD, et al. Large cell non-Hodgkin's lymphoma of childhood. Characteristics and outcome. Leukemia 1994;8:30-34.
Lones MA, Perkins SL, Sposto R, Kadin M, Kjeldsborg CR, Wilson JF, et al. Large cell lymphoma arising in the mediastinum in children and adolescents is associated with excellent outcome: a Children's Cancer Group report. J Clin Oncology 2000;18:3845-3853.
https://doi.org/10.1200/JCO.2000.18.22.3845
Hutchison RE, Pui CH, Murphy SB. Non-Hodgkin's lymphoma in children younger than 3 years. Cancer 1988;62:1371-1373.
https://doi.org/10.1002/1097-0142(19881001)62:7<1371::AID-CNCR2820620722>3.0.CO;2-Y
Link MP, Shuster JJ, Donaldson SS. Treatment of children and young adults with early-stage non-Hodgkin's lymphoma. N Engl J Med 1997;337: 1259-1266.
https://doi.org/10.1056/NEJM199710303371802
Murphy SB, Fairclough DL, Hutchinson RE, Berar CW. Non-Hodgkin's lymphoma: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution. J Clin Oncol 1989;7: 186-193.
https://doi.org/10.1200/JCO.1989.7.2.186
Anderson JR, Jenkin DT, Wilson JF, Kieldsbeerg CR, Sposto R, Robert R, et al. Long-term follow up of patients treated with COMP or LSA2L2 therapy for childhood non-Hodgkin's lymphoma: a report of CCG-551 from the Children's Cancer Group. J Clin Oncology 1993;11:1024-1032.
https://doi.org/10.1200/JCO.1993.11.6.1024
Cairo MS, Sposto R, Hoover-Regan M, Meadows AT, Anderson JR, Siegel SE, et al. Chilhood and adolescent large-cell lymphoma (LCL): a review of the Childrens's Cancer Group experience. Am J Hematol 2003;72:53-63.
https://doi.org/10.1002/ajh.10262
Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink K, Verdiman J, et al. World Health Organization classification of neoplastic diseases of the hematopoyetic and lymphoid tissues: report of the Clinical Advisory Committee Meeting (Airlie House, Virginia, November 1997). J Clin Oncol 1999;17:3835-3849.
https://doi.org/10.1200/JCO.1999.17.12.3835
Foss HD, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer JA, et al. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood 1996;88(10): 4005-4011.
https://doi.org/10.1182/blood.V88.10.4005.bloodjournal88104005
Seidemann K, Tiemann M, Schrappe M, Yakisan E, Simonitsch I, Janka-Scjaub G, et al. Short-pulse B non-Hodgkin lymphoma type chemotherapy is efficacious treatment for pediatric anaplastic large-cell lymphoma: a report of the Berlin-Frankfurt-Miinster Group (Trial NHL-BFM90). Blood 2001;97(2): 3699-3706.
https://doi.org/10.1182/blood.V97.12.3699
Reiter A, Scharappe M, Ludwig WD, Tieman M, Parwarsh R, Zimmermann M, et al (on behalf of the Berlin-Frankfurt-Mtlnster Group. Intensive all-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoma: a BFM Group report. Blood 2000;95 (2):416-421.
Sandlund JT, Downing JR, Crist WM. Non-Hodgkin's lymphoma in childhood. N Engl J Med 1996;334(19): 1238-1248.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Todos los derechos reservados.
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |