Primary non-Hodgkin’s lymphomas of the breast: 23 years of experience at the Colombian National Cancer Institute
Keywords:
Lymphoma, breast lymphoma, extranodal, non-Hodgkin’s lymphomas, breast cancerAbstract
Introducción: Primary non-Hodgkin’s lymphomas of the breast (PNHLB) are an infrequent malignancy. In a review of the literature, in which six Latin American journals are included, approximately 450 cases have been reported during the past two decades. In this paper we present the experience of the National Cancer Institute of Colombia during the last 23 years.
Objective: To carry out a retrospective analysis of the characteristics, natural history, prognostic factors, and outcome of patients with PNHLB at the nci of Colombia.
Methods: The medical histories of patients diagnosed with PNHLB between 1980 and 2003 were reviewed; likewise, the clinical characteristics, treatment protocols, and final outcomes were analyzed.
Results: 25 patients were identified as PNHLB. The average follow-up was 57 months. The medium age was 58, ranging from 26 to 83. 84% had diffused large cell lymphoma. The Kamofsky index was over 80 in 92 % of the patients. 72% received CHOP chemotherapy. Two patients received a combination without doxorubicin. 68% received combined chemo- and radiation therapy. Two patients refused therapy. Two patients died before receiving any type of treatment. CNS compromise was observed in 20% of patients during the evolution of their disease. The youngest patient, whose case deserves special comment, obtained a second complete remission with simple mastectomy, after having relapsed after conventional chemotherapy, radiotherapy, and autologous bone marrow transplant. No significant prognostic variables were found using the univariate analysis.
Conclusions: A high rate of complete remission can be achieved by using combined treatment in patients with PNHLB. The medium overall survival was not reached after 71 months of follow-up. The most frequent relapse site was the cns.
Author Biographies
Myriam Rodríguez, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología, E.S.E, Clínica de Hematología y Trasplante de Médula Ósea, Bogotá D.C.
Marco Grajales, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología, E.S.E, Clínica de Hematología y Trasplante de Médula Ósea, Bogotá D.C.
Sonia Londoño, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología, E.S.E, Especialista en Entrenamiento, Clínica de Ginecología Oncológica, Bogotá D.C.
Natascha Ortiz, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología, E.S.E, Grupo Investigación Clínica, Bogotá D.C.
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