Meningeal carcinomatosis as first manifestation of gastric carcinoma
Keywords:
Meningeal carcinomatosis, stomach neoplasms, autopsy, immunohistochemistry.Abstract
Meningeal carcinomatosis is defined as the malignant and widespread infiltration of the meninges due to the planting and growth of cancer cells within the leptomeningeal space. It occurs more frequently in patients with disseminated neoplastic disease, but it may occur after a disease free interval and may even be the first manifestation of cancer. The most common primary tumors in adults are breast (30-50%), lung (15-25%), melanoma (11%) and gastric cancer (0.16-0.69%); in marked contrast with pediatric cases in which lymphocytic leukemia is the most common. The following article describes an autopsy case of a patient with psychiatric symptoms, with no antecedents of importance, with progressive and fatal neurological impairment, whose pathological studies show meingeal carcinomatosis attributable to advanced gastric adenocarcinoma discovered de novo post mortem.
Author Biographies
Alfredo Ernesto Romero Rojas, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá. Colombia.
Julio César Mantilla Hernández, Universidad Industrial de Santander
Grupo de patología, Universidad Industrial de Santander, Bucaramanga. Colombia.
Mario Alexánder Melo Uribe, Universidad Industrial de Santander
Grupo de patología, Universidad Industrial de Santander, Bucaramanga. Colombia.
Paula Alejandra Barajas Solano, Universidad Industrial de Santander
Grupo de patología, Universidad Industrial de Santander, Bucaramanga. Colombia.
Sandra Isabel Chinchilla Olaya, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá. Colombia.
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