Magnetic resonance spectrum analysis
Keywords:
Magnetic resonance images, Magnetic resonance spectroscopy, Magnetic, Metabolites, Quantification, Reproducibility, PRESSAbstract
Objective: To study the performance in the use of metabolite ratios and the comparison of a contralateral volume of interest in order to determine which of these two techniques is most suitable for obtaining a ratio of the metabolite behaviour of a magnetic resonance spectrum.
Methods: The parietal lobe, the temporal lobe, and basal ganglions were analysed in the 10 healthy volunteers included in the study.
Results: The direct quantification of the spectra showed a wide coefficient of variation within the analyses performed, which justified using techniques with endogenous references. The study of a contralateral volume showed to be a technique with a high dispersion and laterality index. The use of creatinine (Cr) as a control metabolite had a lower coefficient of variation than the first technique evaluated. The results obtained (basal ganglions: N‐acetyl‐aspartate/ Cr: 3 ± 6; choline/Cr: 2 ± 4. Temporal lobe: N‐acetyl‐aspartate/Cr: 5 ± 5; choline/Cr: 8 ± 12. Parietal lobe: n-acetyl-aspartate/Cr: 2.0 ± 0.6; choline/Cr: 0.9 ± 0.5) showed similar values to those obtained in the literature, with considerable anatomical region variations.
Conclusions: The technique that measures the ratio of the metabolites with Cr is the most suitable for use in the Instituto Nacional de Cancerología (national Oncology institute), due to having a lower dispersion and producing results near those reported in the literature in the different anatomical regions studied.
Author Biographies
Alfonso Lozano, Instituto Nacional de Cancerología
Grupo de Radiología e Imágenes Diagnósticas, Instituto Nacional de Cancerología, ESE, Bogotá, D. C., Colombia
Departamento de Imágenes Diagnósticas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D. C., Colombia
Nathaly Barbosa, Universidad Nacional de Colombia
Grupo de Física Médica y Radiológica, Departamento de Física, Universidad Nacional de Colombia, Bogotá, D. C., Colombia
Grupo de Medicina Nuclear, Instituto Nacional de Cancerología. ESE, Bogotá, D. C., Colombia
Luis Agulles, Universidad Nacional de Colombia
Grupo de Física Médica y Radiológica, Departamento de Física, Universidad Nacional de Colombia, Bogotá, D. C., Colombia
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