Magnetic resonance spectrum analysis
Keywords:
Magnetic resonance images, Magnetic resonance spectroscopy, Magnetic, Metabolites, Quantification, Reproducibility, PRESSAbstract
Objective: To study the performance in the use of metabolite ratios and the comparison of a contralateral volume of interest in order to determine which of these two techniques is most suitable for obtaining a ratio of the metabolite behaviour of a magnetic resonance spectrum.
Methods: The parietal lobe, the temporal lobe, and basal ganglions were analysed in the 10 healthy volunteers included in the study.
Results: The direct quantification of the spectra showed a wide coefficient of variation within the analyses performed, which justified using techniques with endogenous references. The study of a contralateral volume showed to be a technique with a high dispersion and laterality index. The use of creatinine (Cr) as a control metabolite had a lower coefficient of variation than the first technique evaluated. The results obtained (basal ganglions: N‐acetyl‐aspartate/ Cr: 3 ± 6; choline/Cr: 2 ± 4. Temporal lobe: N‐acetyl‐aspartate/Cr: 5 ± 5; choline/Cr: 8 ± 12. Parietal lobe: n-acetyl-aspartate/Cr: 2.0 ± 0.6; choline/Cr: 0.9 ± 0.5) showed similar values to those obtained in the literature, with considerable anatomical region variations.
Conclusions: The technique that measures the ratio of the metabolites with Cr is the most suitable for use in the Instituto Nacional de Cancerología (national Oncology institute), due to having a lower dispersion and producing results near those reported in the literature in the different anatomical regions studied.
Author Biographies
Alfonso Lozano, Instituto Nacional de Cancerología
Grupo de Radiología e Imágenes Diagnósticas, Instituto Nacional de Cancerología, ESE, Bogotá, D. C., Colombia
Departamento de Imágenes Diagnósticas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D. C., Colombia
Nathaly Barbosa, Universidad Nacional de Colombia
Grupo de Física Médica y Radiológica, Departamento de Física, Universidad Nacional de Colombia, Bogotá, D. C., Colombia
Grupo de Medicina Nuclear, Instituto Nacional de Cancerología. ESE, Bogotá, D. C., Colombia
Luis Agulles, Universidad Nacional de Colombia
Grupo de Física Médica y Radiológica, Departamento de Física, Universidad Nacional de Colombia, Bogotá, D. C., Colombia
References
Reiser MF, Semmler W, Hricak H. Magnetic resonance tomography. Berlin Heidelberg: Springer‐Verlag; 2008.
https://doi.org/10.1007/978-3-540-29355-2
Block W, Träber F, Flacke S, Jessen F, Pohl C, Schild H. In‐vivo proton MR‐spectroscopy of the human brain: Assessment of N‐acetylaspartate (NAA) reduction as a marker for neurodegeneration. amino acids. 2002;23:317-23.
https://doi.org/10.1007/s00726-001-0144-0
Butscher IM, Holtas S.Proton magnetic resonance spectroscopy in brain tumors: clinical applications. neuroradiology. 2001;43: 345‐52.
https://doi.org/10.1007/s002340000427
Gujar SK, Maheshwari S, Björkman‐Burtscher I, Sundgren PC. Magnetic resonance spectroscopy. J Neuro‐Ophthalmol. 2005; 25:217‐26.
https://doi.org/10.1097/01.wno.0000177307.21081.81
Mathews VP, Barker PB, Blackband SJ, Chatham JC, Bryan RN. Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy. Am J Roentgenol. 1995;165:633‐8.
https://doi.org/10.2214/ajr.165.3.7645484
Möller‐Hartmann W, Herminghaus S, Krings T, Marquardt G, lanfermann H, Pilatus U, et al. Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology. 2002;44:371-81.
https://doi.org/10.1007/s00234-001-0760-0
Knight‐Scott J, Haley AP, Rossmiller SR, Farace E, Mai WM, Christopher JM, et al. Molality as a unit of measure for expressing 1H MRS brain metabolite concentrations in vivo, Magn Reson imaging. 2003;21:787-97.
https://doi.org/10.1016/S0730-725X(03)00179-6
JansenJF,BackesWH,NicolayK,KooiME.1HMRspectroscopy of the brain: absolute quantification of metabolites. Radiology. 2006;240:318-32.
https://doi.org/10.1148/radiol.2402050314
Michaelis T, Merboldt KD, Bruhn H, Hänicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra. Radiology.1993; 187:219-27.
https://doi.org/10.1148/radiology.187.1.8451417
Christiansen P, Henriksen O, Stubgaard M, Gideon P, Larsson HBW. In vivo quantification of brain metabolites by 1H‐MRS using water as an internal standard. Magn Reson imaging. 1993;11-1:107-18.
https://doi.org/10.1016/0730-725X(93)90418-D
Tofts PS,Wray S.A critical assessment of methods of measuring metabolite concentrations by nMR spectroscopy. nMR Biomed. 1988;1:1-10.
https://doi.org/10.1002/nbm.1940010103
li BS, Wang H, gonen O. Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy. Magn Reson imaging. 2003;21:923-8.
https://doi.org/10.1016/S0730-725X(03)00181-4
Stefan D,DiCesare F,andrasescua,Popa E,etal. Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package. Meas Sci Technol. 2009. doi:10.1088/0957‐0 233/20/10/104035.
https://doi.org/10.1088/0957-0233/20/10/104035
Minati L, Aquino D, Bruzzone Mg, Erbetta a. Quantitation of normal metabolite concentrations in six brain regions by in vivo 1H MR spectroscopy. J Med Phys. 2010;35:154‐63.
https://doi.org/10.4103/0971-6203.62128
Webb PG, Sailasuta N, Kohler SJ, Raidy T, Moats RA, Hurd RE. Automated Single‐Voxel Proton MRS: technical development and multisite verification. MRM. 1994;31:365‐73.
https://doi.org/10.1002/mrm.1910310404
Simmons A, Smail M, Moore E, Williams S. Serial precision of metabolite peak area ratios and water referenced metabolite peak areas in proton mr spectroscopy of the human brain. Magn Reson imaging. 1998;16:319-30.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Todos los derechos reservados.
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |