Sentinel Node Biopsy in Breast Cancer After Neoadjuvant Therapy in a Latin-American population
Keywords:
Sentinel Lymph Node Biopsy, Axillary clearance, Breast Neoplasms, Neoadjuvant TherapyAbstract
Objective: To determine the usefulness of sentinel node biopsy in breast cancer after neoadjuvant treatment.
Methods: A study of a diagnostic test.
Results: The analysis was carried out on 67 Latin-American patients treated in the Instituto Nacional de Cancerología (Bogotá, Colombia), obtaining an axillary migration rate of 85%. The sentinel node identification rate was 90%. The false negative rate is 25%. The performance of the diagnostic test shows a sensitivity of 75%, specifity of 100%, positive predictive value of 100%, negative predictive value of 77.5%, and 85.6% accuracy.
Conclusions: The results of our study show that this technique is not recommended as standard procedure, even in patients with clinically negative axilla confirmed by axillary ultrasound. The high percentage of false negatives may be due to the high number of patients with locally advanced disease in our series.
Author Biographies
Javier Ángel Aristizaba, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Sebastián Quintero, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Fellow Cirugía de Mama y Tumores de Tejidos Blandos, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia
Alejandro Orozco, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
María Claudia Ramírez, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Claudia Cubillos, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Fellow Cirugía de Mama y Tumores de Tejidos Blandos, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia
Alejandra Sánchez, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Fellow Cirugía de Mama y Tumores de Tejidos Blandos, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia
Edward Casas, Instituto Nacional de Cancerología
Grupo de Seno y Tejidos blandos, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Fellow Cirugía de Mama y Tumores de Tejidos Blandos, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia
Cesar Poveda, Instituto Nacional de Cancerología
Servicio Imágenes Diagnósticas, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Juan Carlos Hidalgo, Instituto Nacional de Cancerología
Servicio Imágenes Diagnósticas, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Augusto Llamas Olier, Instituto Nacional de Cancerología
Grupo de Medicina Nuclear, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Oscar Alberto Messa, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Erika León, Instituto Nacional de Cancerología
Grupo Área Investigación Clínica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
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