Breast amphicrine carcinoma. Report of an unusual case
Keywords:
Amphicrine tumor, Breast carcinoma, Chromogranin A, Synaptophysin, AdenoneuroendocrineAbstract
Amphicrine tumours of the mammary gland are very rare dual lesions with epithelial and neuroendocrine differentiation in the same cell. We report the case of a woman with a mass in the right breast. The histopathology study showed a malignant tumour formed by small cells inter-mixed with some cells with a signet ring appearance. The use of antibodies showed immunoreactivity for epithelial and neuroendocrine markers in the malignant cells. These characteristics enable the diagnosis of an amphicrine tumour, based on the expression of epithelial and neuroendocrine markers in the same cell. The differential diagnosis must be made with collision tumours or with metastasis. The rigorous interpretation of the immunohistochemistry in the malignant cells in an amphicrine tumour is useful in order to distinguish this tumour from other diseases with similar morphological characteristics.
Author Biographies
Camilo Andrés Silva Barbosa, Instituto Nacional de Cancerología
Patología, Universidad Militar Nueva Granada- Programa Instituto Nacional de Cancerología, Bogotá D. C., Colombia
María Camila Álzate Meza, Universidad de Manizales
Facultad de Medicina, Universidad de Manizales, Manizales, Colombia
Oscar Alberto Messa Botero, Instituto Nacional de Cancerología
Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
Sandra Isabel Chinchilla Olaya, Instituto Nacional de Cancerología
Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
Alfredo Ernesto Romero Rojas, Instituto Nacional de Cancerología
Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
Grupo Tumores Neuroendocrinos, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
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