Mesenteric extragastrointestinal stromal tumor (EGIST): a rare variant with unusual behaviour

Authors

  • Beatriz Peláez-Lorenzo Hospital Clínico Universitario de Valladolid
  • Carlos A. Rodríguez Arias Hospital Clínico Universitario de Valladolid
  • Luis Alberto Mata Juberías Hospital Universitario la paz

Keywords:

EGIST, Skull metastasis, Surgery, Imatinib

Abstract

Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the gastrointestinal tract. Those GIST arising outside the gastrointestinal tract are called extra-gastrointestinal stromal tumours (EGIST) and share clinical, pathological and molecular features. They are very rare and very little is known about the correct management and prognosis of these neoplasms. The case is presented of a patient with a mesenteric EGIST and an unusual outcome. Its differential diagnosis is difficult, and the need for a multidisciplinary team approach is emphasised.

Author Biographies

Beatriz Peláez-Lorenzo, Hospital Clínico Universitario de Valladolid

Servicio de Oncología, Hospital Clínico Universitario de Valladolid, Valladolid, España

Carlos A. Rodríguez Arias, Hospital Clínico Universitario de Valladolid

Servicio de Neurocirugía, Hospital Clínico Universitario de Valladolid, Valladolid, España

Luis Alberto Mata Juberías, Hospital Universitario la paz

Servicio de Cirugía General, Hospital Universitario la paz, Valladolid, España

References

Miettinen M, Lasota J. Gastrointestinal stromal tumors - definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 2001;438:1-12.

https://doi.org/10.1007/s004280000338

Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13:577-85.

https://doi.org/10.1038/modpathol.3880099

Barros A, Linhares E, Valadão M, Gonc¸alves R, Vilhena B, Gil C, et al. Extragastrointestinal stromal tumors (EGIST): a series of case reports. Hepatogastroenterology. 2011;58:865-8.

Iqbal N, Sharma A, Iqbal N. Clinicopathological and treatment analysis of 13 extragastrointestinal stromal tumors of mesentery and retroperitoneum. Ann Gastroenterol. 2015;28:105-8.

Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS, et al. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23:1109-18.

https://doi.org/10.1097/00000478-199909000-00015

Patnayak R, Jena A, Parthasarathy S, Prasad PD, Reddy MK, Chowhan AK, et al. Primary extragastrointestinal stromal tumors: a clinicopathological and immunohistochemical study: a tertiary care center experience. Indian J Cancer. 2013;50:4-5.

https://doi.org/10.4103/0019-509X.112298

Llenas-García J, Guerra-Vales JM, Moreno A, Ibarrola C, Castelbon FJ, Fernández-Ruiz M, et al. Primary extragastrointestinal stromal tumors in the omentum and mesentery: a clinicopathological and immunohistochemical study. Hepatogastroenterology. 2008;55:1002-5.

Yi JH, Park BB, Kang JH, Hwang IG, Shin DB, Sym SJ, et al. Retrospective analysis of extra-gastrointestinal stromal tumors. World J Gastroenterol. 2015;21:1845-50.

https://doi.org/10.3748/wjg.v21.i6.1845

Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, et al. c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol. 2004;28:479-88.

https://doi.org/10.1097/00000478-200404000-00007

Gil-Arnaiz I, Martínez-Trufero J, Pazo-Cid R, Felipo F, Lecumberri MJ, Calderero V. Skull metastasis from rectal gastrointestinal stromal tumours. Clin Transl Oncol. 2009;11:625-7.

https://doi.org/10.1007/s12094-009-0415-x

Romero Rojas AE, Mesa Botero OA, Melo Uribe MA, Chinchilla Olaya SI, Barajas Solano PA. Tumor del estroma gastrointestinal gástrico con metástasis inusual al cráneo. Rev Col Gastroenterol. 2011;26:311-5.

Gastrointestinal Stromal Tumor Meta-Analysis Group (Meta- GIST). Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients. J Clin Oncol. 2010;28:1247-53.

https://doi.org/10.1200/JCO.2009.24.2099

Blanke CD, Rankin C, Demetri GD, Ryan CW, von Mehren M, Benjamin RS, et al. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol. 2008;26:626-32.

https://doi.org/10.1200/JCO.2007.13.4452

Poveda A, del Muro XG, López-Guerrero JA, Martínez V, Romero I, Valverde C, et al. GEIS 2013 guidelines for gastrointestinal sarcomas (GIST). Cancer Chemother Pharmacol. 2014;74: 883-98.

https://doi.org/10.1007/s00280-014-2547-0

How to Cite

[1]
Peláez-Lorenzo, B. et al. 2016. Mesenteric extragastrointestinal stromal tumor (EGIST): a rare variant with unusual behaviour. Revista Colombiana de Cancerología. 20, 2 (Jun. 2016), 87–91.

Downloads

Download data is not yet available.

Published

2016-06-01

Issue

Section

Reportes de caso
Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views