Neuroendocrine rectal carcinoma: An infrequent tumour
Keywords:
Neuroendocrine carcinoma, Drug therapy, Rectal tumoursAbstract
Neuroendocrine carcinoma (NC) is an infrequent pathology that is usually found in the advanced stages. The treatment is surgery, and combined chemotherapy andradiotherapy. A 73-yearold woman was being studied for constitutional syndrome and rectal bleeding. After which, she was diagnosed with a poorly differentiated rectal NC, 5 cm from de anal margin with mesorectal lymph nodes. Induction chemotheraphy was started with partial response.
A low anterior resection of rectum was performed with primary anastomoses and diverting loop ileostomy. The histology result was a large-cell NC, staged as pT2N0 Mx. She then received adjuvant chemotherapy. Rectal NC is infrequent, and usually presents between the fourth and seventh decade of life. Its symptoms are similar to colorectal adenocarcinoma, but it has a lower grade of differentiation, and is more aggressive. Neoadjuvant treatment is essential as it usually a metastatic disease at diagnosis, and helps to decrease the tumour size, and and allows oncological surgery to be performed later.
Author Biographies
Eduardo Pérez-Sánchez, Hospital Universitario Nuestra Señora de Candelaria
Unidad de Coloproctología, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, España
Moisés Hernández-Barroso, Hospital Universitario Nuestra Señora de Candelaria
Unidad de Coloproctología, Servicio de Cirugía General y del Aparato Digestivo,Hospital Universitario Nuestra Señora de Candelaria, Tenerife, España
Guillermo Hernández-Hernández, Hospital Universitario Nuestra Señora de Candelaria
Unidad de Coloproctología, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, España
Luisa Gambra-Michel, Hospital Universitario Nuestra Señora de Candelaria
Unidad de Coloproctología, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, España
Manuel Barrera-Gómez, Hospital Universitario Nuestra Señora de Candelaria
Unidad de Coloproctología, Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, España
References
Vázquez Ruiz J, Martín Díaz L, Mansilla Molina D, Guirao Manzano J, Pérez Folqués JE, Civera Muñoz, et al. Neuroendocrine carcinoma of colon and rectum. Cir Esp. 2000;67:625-7.
Smith JD, Reidy DL, Goodman KA, Shia J, Nash GM. A Retrospective Review of 126 High-Grade Neuroendocrine Carcinomas of the Colon and Rectum. Ann Surg Oncol. 2014;21:2956-62.
https://doi.org/10.1245/s10434-014-3725-3
Garcia-Carbonero R, Capdevila J, Crespo-Herrero G, Díaz-Pérez JA, Martínez del Prado MP, Alonso Orduña V, et al. Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): Results from the National Cancer Registry of Spain (RGETNE). Ann Oncol. 2010;21:1794-803.
https://doi.org/10.1093/annonc/mdq022
Lai CC, Wang CW, Changchien CR, Tang R, Chiang JM, You YT, et al. Neuroendocrine carcinomas of the colon and rectum: Result of a 15-year experience. J Soc Colon Rectal Surgeon. 2008;19:87-95.
Nojima H, Seike K, Kosugi C, Shida T, Koda K, Oda K, et al. Advanced moderately differentiated neuroendocrine carcinoma of the rectum with favorable prognosis by posoperative chemoradiation. World J Surg Oncol. 2010;8:29.
https://doi.org/10.1186/1477-7819-8-29
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz S, Shi W, et al. Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum. 2004;47:163-9.
https://doi.org/10.1007/s10350-003-0038-1
Prieto-Montaño J, Salazar W, Reyna-Villasmil E, de Nobrega- Correa H. Carcinoma neuroendocrino de células peque˜nas de colon. Gastroenterol Hepatol. 2011;34:54-6.
https://doi.org/10.1016/j.gastrohep.2010.09.005
Errasti Alustiza J, Espín Basany E, Reina Duarte A. Rare tumors of the rectum. Narrative review. Cir Esp. 2014;92:579-88.
https://doi.org/10.1016/j.ciresp.2013.06.019
Minocha V, Shuja S, Ali R, Eid E. Large cell neuroendocrine carcinoma of the rectum presenting with extensive metastasic disease. Case Rep Oncol Med. 2014;2014:386379.
https://doi.org/10.1155/2014/386379
Lee JL, Yu CS, Kim M, Hong SM, Lim SB, Kim JC. Prognostic impact of diagnosing colorectal neuroendocrine carcinoma using the World Health Organization 2010 classification. Surgery. 2014;155:650-8.
https://doi.org/10.1016/j.surg.2013.11.012
Marín A, Vergara J, Espíndola L, Sandoval R. Tumor neuroendocrino de células pequeñas de anorrecto. Rev Chilena de Cirugía. 2003;55:513-7.
Starzy'nskal T, Londzin-Olesik M, Bałdys-Waligórska A, Bednarczuk T, Blicharz-Dorniak J, Bolanowski M, et al. Colorectal neuroendocrine neoplasms - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Polska. 2017;68.
Vardas K, Papadimitriou G, Chantziara M, Papakonstantinou A, Drakopoulos S. Mixed large cell neuroendocrine carcinoma with squamous cell carcinoma of the rectum: Report of a rare case and review of the literature. Int J Surg Case Rep. 2013;4:1076-9.
https://doi.org/10.1016/j.ijscr.2013.08.021
Sorbye H, Welin S, Langer SW, Vestermark LW, Holt N, Osterlund P, et al. Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): The NORDIC NEC study. Ann Oncol. 2013;24: 152-60.
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