Primary breast squamous metaplastic squamous cell carcinoma: of the breast: a rare subtype. Presentation of three cases in the Hospital Universitario del Caribe
Keywords:
Metaplastic breast carcinoma, Squamous cell carcinoma of the breast, Breast carcinomaAbstract
Ductal carcinomas are the most common of all breast malignancies, less than 5% are of metaplastic nature, and 0.04% to 0.1% have squamous cell differentiation. These special subtypes are considered more aggressive. Due to the few cases in the literature, there is no consensus about its diagnosis and treatment. Three cases are presented with this diagnosis, seen in our institution between 2014 and 2015. They were women of 57, 49, and 65 years old with no risk factors, and who presented with similar clinical features, consisting of the appearance of a rapid growing mass. Two of the patients had been previously diagnosed with infiltrating ductal carcinoma of no special type by core needle biopsy, with a definitive diagnosis in radical mastectomy, which reported squamous metaplastic carcinoma confirmed by immunohistochemistry.
Author Biographies
Saúl Andrés Rivero Monterrosa, Universidad de Cartagena
Posgrado de Patología, Facultad de Medicina, Universidad de Cartagena, Cartagena de Indias, Bolívar, Colombia
Karoll D Robles Pérez, Universidad de Cartagena
Posgrado de Patología, Facultad de Medicina, Universidad de Cartagena, Cartagena de Indias, Bolívar, Colombia
Olivia Marrugo Grice, Universidad de Cartagena
Departamento de Patología, Facultad de Medicina, Universidad de Cartagena, Cartagena de Indias, Bolívar, Colombia
César Redondo Bermúdez, Universidad de Cartagena
Departamento de Patología, Facultad de Medicina, Universidad de Cartagena, Cartagena de Indias, Bolívar, Colombia
References
Rosen PP. Carcinoma with metaplasia. En: Rosen PP, editor. Breast Pathology. 3 rd ed. Filadelfia: Lippincott Williams & Wilkins; 2009. p. 471-505.
Moinfar F. Special types of breast carcinomas. Metaplastic carcinomas. En: Moinfar F, editor. Essentials of diagnostic breast pathology. Leipzig: Distribution Center GmbH; 2007. p. 234-6.
Beatty JD, Atwood M, Tickman R, Reiner M. Metaplastic breast cancer: clinical significance. Am J Surg. 2006;191:657-64.
https://doi.org/10.1016/j.amjsurg.2006.01.038
Aparicio I, Martínez A, Hernández G, Hardisson D, De Santiago J. Squamous cell carcinoma of the breast. Eur J ObstetGynecol- ReprodBiol. 2008;137:222-6.
https://doi.org/10.1016/j.ejogrb.2007.03.021
Gupta C, Malani AK, Weigand RT, Rangineni G. Pure primary squamous cell carcinoma of the breast: a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast. PatholResPract. 2006;202:465-9.
https://doi.org/10.1016/j.prp.2006.01.006
Yang WT, Hennessy B, Broglio K, Mills C, Sneige N, Davis WG, et al. Imaging differences in metaplastic and invasive ductal carcinomas of the breast. AJR Am J Roentgenol. 2007;189:1288-93.
https://doi.org/10.2214/AJR.07.2056
Vokes EE, Kies MS, Haraf DJ, Stenson K, List M, Humerickhouse R, et al. Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer. J ClinOncol. 2000;18:1652-61.
https://doi.org/10.1200/JCO.2000.18.8.1652
Yigit S, Pehlivan F, Evcim G, Etit D. Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases. Pathol Res Pract. 2012;208:147-50.
https://doi.org/10.1016/j.prp.2011.12.014
Reis-Filho JS, Lakhani SR, Gobbi H, Sneige N. Metaplastic carcinoma. En: Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ, editores. World Health Organization Classification of Tumours of the Breast. Lyon, Francia: IARC Press; 2012. p. 48-52.
Oberman HA. Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients. Am J SurgPathol. 1987;11:918-29.
https://doi.org/10.1097/00000478-198712000-00002
Ng SP, Sheu CY, Cheng SM. Small Metaplastic Carcinoma of the Breast: A Case Report. J Med Ultrasound. 2003;11:118-21.
https://doi.org/10.1016/S0929-6441(09)60049-7
Carbonea S, Lobo R, Lamacchia A, Almenar Gil A, Martin Hernandez R, Lopez Guerra JL, et al. Primary squamous cell carcinoma of the breast: A rare case report. Rep PractOncolRadiother. 2012;17:363-6.
https://doi.org/10.1016/j.rpor.2012.07.004
Niño-Hernández L, García-Toloza R, Donado F, Pérez J, Arteta- Acosta C, Aroca G. Carcinoma metaplásico de la mama tipo células escamosas: reporte de caso y revisión de la literatura. Rev ColombObstetGinecol. 2011;62:261-6.
Tse GM, Tan PH, Putti TC, Lui PC, Chaiwun B, Law BK. Metaplastic carcinoma of the breast: a clinicopathological review. J ClinPathol. 2006;59:1079-83.
https://doi.org/10.1136/jcp.2005.030536
Tavassoli FA, Devilee P. Tumours of the breast. Metaplastic carcinomas. En: Tavassoli FA, Devilee P, editores. Pathology and genetics of tumours of the breast and female genital organs. World Health Organization of Classification of Tumours. Lyon, Francia: IARC Press; 2003. p. 37-40.
Okada N, Hasebe T, Iwasaki M, Tamura N, Akashi-Tanaka S, Hojo T, et al. Metaplastic carcinoma of the breast. Hum Pathol. 2010;41:960-70.
https://doi.org/10.1016/j.humpath.2009.11.013
Grenier J, Soria JC, Mathieu MC, Andre F, Abdelmoula S, Velasco V, et al. Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res. 2007;27:547-55.
vanDeurzen CH, Lee AH, Gill MS, Menke-Pluijmers MB, Jager A, Ellis IO, et al. Metaplastic breast carcinoma: tumourhistogenesis or dedifferentiation? J Pathol. 2011;224:434-7.
https://doi.org/10.1002/path.2872
Luini A, Aguilar M, Gatti G, Fasani R, Botteri E, Brito JA, et al. Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature. Breast Cancer Res Treat. 2007;101:349-53.
https://doi.org/10.1007/s10549-006-9301-1
Park HS, Park S, Kim JH, Lee JH, Choi SY, Park BW, et al. Clinicopathologicfeatures and outcomes of metaplastic breast carcinoma: comparison with invasive ductal carcinoma of the breast. Yonsei Med J. 2010;51:864-9.
https://doi.org/10.3349/ymj.2010.51.6.864
Gibson GR, Qian D, Ku JK, Lai LL. Metaplastic breast cancer: clinical features and outcomes. Am Surg. 2005;71:725-30.
Rivero León A, Núñez Calatayud M, Rivero Nú˜nez H, Rivero León A. Carcinoma metaplásicoepidermoide primario de la mama. Reporte de un caso. Cancer. 2009;48:321-4.
Bae SY, Lee SK, Koo MY, Hur SM, Choi MY, Cho DH, et al. The prognoses of metaplastic breast cancer patients compared to those of triple-negative breast cancer patients. Breast Cancer Res Treat. 2011;126:471-8.
https://doi.org/10.1007/s10549-011-1359-8
Choi BB, Shu KS. Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Acta Radiol. 2012;53:5-11.
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