Arteriovenous malformation masking associated anaplastic ganglioglioma in an adolescent
Keywords:
Brain tumour, Child, Intracranial hypertension, Ganglioglioma, HeadacheAbstract
Grade III anaplastic ganglioglioma is an aggressive, rare, and radiosensitive central nervous system (CNS) tumour. It is more common in males, with a ratio of 1.3 to 1. Its peak incidence is in the third decade of life. Only 10 cases were recorded in children in Colombia from 2000 to 2014, with a fatal outcome in spite of radiation therapy. This is a case of an adolescent, who began having headaches, with warning signs related to an arteriovenous malformation hindering the diagnosis of this rare tumour. This presented in its aggressive, multi-focus form. Knowledge of clinical manifestations of space-occupying intracranial lesions facilitates the assessment and treatment of affected children.
Author Biographies
Gustavo Adolfo Carvajal-Barrios, Universidad el Bosque
Physician, pediatrics resident, Universidad el Bosque, Bogotá D. C, Colombia
Jimena Ortiz, Hospital Militar Central
Neuroradiologist, professor ad honorem, Universidad Militar Nueva Granada (UMNG)-Hospital Militar Central (HMC), Bogotá D.C, Colombia
Natalia González, Hospital Militar Central
Pediatric hematologist/oncologist, HMC-HMC, Bogotá D. C, Colombia
José Arias, Hospital Militar Central
Pathologist, HMC. Professor ad honorem UMNG-HMC, Bogotá D. C, Colombia
Fernando Velandia, Universidad del Rosario
Neuropathologist, Senior professor, Neuroscience Group, Universidad del Rosario, Bogotá D. C, Colombia
Pilar Guerrero, Hospital Militar Central
Pediatric neurologist, associate professor of pediatric neurology, UMNG-HMC, Bogotá D. C, Colombia
Eugenia Espinosa, Hospital Militar Central
Pediatric neurologist, tenured profesor in pediatric neurology UMNG-HMC, Coordinator of graduate studies in pediatric
neurology UMNG-HMC, Bogotá D. C, Colombia
References
U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999-2013 Incidence and Mortality Web-based Report. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute; [Acceso en enero 24 de 2017]2016. Disponible en: www.cdc.gov/uscs
Parsons DW, Pollack IF, Hass-Kogan DA, Pussaint TY, Adesina AM, Chitagumpala MM, et al. In: Pizzo PA, Poplack DG, editors. Gliomas, Ependymomas, and Other Nonembryonal Tumors of the Central Nervous System. Seventh edition Philadelphia: Wolter-Kluwer; 2016. p. 628-70. Chapter 26.
Louis DN, Ohgaki H, Wiestler OD, Cavenne WK, Ellison DW, Figarella-Branger D. Neuronal and miwed neuronal-glial tumours. En: WHO classificaction of tumors of the central nervous system. Fourth edition Lyon: WHO; 2016. p. 131-41. Chapeter 6.
https://doi.org/10.1007/s00401-016-1545-1
SEER [Base de datos en línea]; Bethesda: Surveillance Research Program; 1975- [Acceso en noviembre 17 de 2016]; 2016. Disponible en: https://seer.cancer.gov/csr/19752013/resultsmerged/sect29childhoodcancericcc.pdf
Grupo de Vigilancia Epidemiológica del Cáncer, Instituto Nacional de Cancerología de Colombia. Distribución de casos nuevos de gangliogliomas anaplásicos por edad y sexo [reporte no publicado], 2000-2014.
Papetti L, Capuano A, Tarantino S, Vigevano F, Valeriani M. Headache as an emergency in children and adolescents. CurrPain Headache Rep. 2015;19:3.
https://doi.org/10.1007/s11916-015-0480-5
Roser T, Bonfert M, Ebinger F, Blankenburg M, Ertl-Wagner B, Heinen F. Primary versus Secondary Headache in Children: A Frequent Diagnostic Challenge in Clinical Routine. Neuropediatrics. 2013;44:34-9.
https://doi.org/10.1055/s-0032-1332743
Alexiou GA, Argyropoulou MI. Neuroimaging in childhood headache: a systematic review. Pediatr Radiol. 2013;43:777-84.
https://doi.org/10.1007/s00247-013-2692-3
Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D. Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol. 2007;8:685-95.
https://doi.org/10.1016/S1470-2045(07)70207-3
Hsiao HJ, Huang JL, Hsia SH, Lin JJ, Huang IA, Wu CT. Headache in the pediatric emergency service: a medical center experience. Pediatr Neonatol. 2014;55:208-12.
https://doi.org/10.1016/j.pedneo.2013.09.008
Callaghan BC, Kerber KA, Pace RJ, Skolarus L, Cooper W, Burke JF. Headache neuroimaging: Routine testing when guidelines recommend against them. Cephalalgia. 2015;35:1144-52.
https://doi.org/10.1177/0333102415572918
Celli P, Scarpinati M, Nardacci B, Cervoni L, Cantore GP. Gangliogliomas of the cerebral hemispheres. Report of 14 Cases with long-term follow-up and review of the literature. Acta Neurochir (Wien). 1993;125(1-4):52-7.
https://doi.org/10.1007/BF01401828
Scoccianti S, Giordano F, Agresti B, Detti B, Cipressi S, Frances- chini D, et al. Pediatric primary anaplastic ganglioglioma: A case report and review of the literature. Pediatr Neurosurg. 2012;48:35-41.
https://doi.org/10.1159/000340067
Gelabert-González M, Amo JM, Arcos Algaba A, Serramito García R, Castro Bouzas D, Díaz Cabana L, et al. Gangliogliomas intracraneales. Revisión de una serie de 20 pacientes. Neurología. 2011;26:405-15.
https://doi.org/10.1016/j.nrl.2010.09.014
Zhang D, Henning TD, Zou LG, Hu LB, Wen L, Feng XY, et al. Intracranial ganglioglioma: clinicopathological and MRI findings in 16 patients. Clin Radiol. 2008;63:80e-91e.
https://doi.org/10.1016/j.crad.2007.06.010
Liu B, Arakawa Y, Murata D, Mineharu Y, Yokogawa R, Tanji M, et al. Clinicopathological, Radiological, and Genetic Analyses of Cerebellar Gangliogliomas with Long-Term Survival. World Neurosurgery. 2016;94:521-8.
https://doi.org/10.1016/j.wneu.2016.07.051
Odia Y. Gangliocytomas and Gangliogliomas: Review of Clinical, Pathologic and Genetic Features. Clin Oncol. 2016;1:1-6.
Mickle PJ. Ganglioglioma in Children. A review of 32 cases at the University of Florida. Pediatr Neurosurg. 1992;18(5-6):310-4.
https://doi.org/10.1159/000120681
Lang FF, Epstein JF, Ransohoff J, Allen JC, Wisoff J, Abbott RI, et al. Central nervous system gangliogliomas. J Neurosurg. 1993;79:867-73.
https://doi.org/10.3171/jns.1993.79.6.0867
Lüdemann W, Banan R, Hartmann C, Bertalanffy H, Di Rocco C. Pediatric Intracranial primary anaplastic ganglioglioma. Childs Nerv Syst. 2016 Dic 5 [Epub ahead of print].
https://doi.org/10.1007/s00381-016-3302-0
Jeevan DS, Neil JA, Mohan A, Tobias M. Hemorrhagic ganglioglioma of the posterior fossa: case report. Pediatr Neurosurg. 2013;49:33-7.
https://doi.org/10.1159/000353992
Kogler A, Hranilovic T, Bozic B, Kogler J. Concomitant bihemi- spheric cerebral ganglioglioma and hemangioma in an 18-month old child: case report. J Child Neurol. 2000;15:244-8.
https://doi.org/10.1177/088307380001500408
Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, et al. Pediatric infratentorial Ganglioglioma. Childs Nerv Syst. 2015;31:1707-16.
https://doi.org/10.1007/s00381-015-2860-x
Prasad GL, Kumar R, Kurwale N, Suri V. Intraventricular gangliogliomas: a review. World Neurosurg. 2016;87:39-44.
https://doi.org/10.1016/j.wneu.2015.11.044
Koelsche C, Wöhrer A, Jeibmann A, Schittenhelm J, Schindler G, Preusser M, et al. Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta Neu- ropathol. 2013;125:891-900.
https://doi.org/10.1007/s00401-013-1100-2
Del Bufalo F, Carai A, Figà-Talamanca L, Pettorini B, Mallucci C, Giangaspero F, et al. Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent. J Translat Med. 2014;12:356.
https://doi.org/10.1186/s12967-014-0356-1
Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014;370:709-22.
https://doi.org/10.1056/NEJMoa1308345
Zanello M, Pages M, Tauziède-Espariat A, Saffroy R, Puget S, Lacroix L, et al. Clinical, imaging, histopathological and molecular characterization of anaplastic ganglioglioma. J Neuropathol Exp Neuro. 2016;75:971-80.
https://doi.org/10.1093/jnen/nlw074
Young Song J, Hoon Kim J, Hyun Cho Y, Jin Kim C, Jung Lee E. Treatment and outcomes for gangliogliomas: a single-center review of 16 patients. Brain Tumor Res Treat. 2014;2:49-55.
https://doi.org/10.14791/btrt.2014.2.2.49
Selvanathan SK, Hammouche S, Salminen HJ, Jenkinson MD. Outcome and prognostic features in anaplastic ganglioglioma: analysis of cases from the SEER database. J Neurooncol. 2011;105:539-45.
https://doi.org/10.1007/s11060-011-0615-4
Majores M, Von Lehe M, Fassunke J, Schramm J, Becker AJ, Simon M. Tumor recurrence and malignant progression of gangliogliomas. Cancer. 2008;113:3355-63.
https://doi.org/10.1002/cncr.23965
Luyken C, Blümcke I, Fimmers R, Urbach H, Wiestler OD, Schramm J. Supratentorial Gangliogliomas: Histopathologic Grading and Tumor Recurrence in 184 patients with a median follow-up of 8 years. Cancer. 2004;101:146-55.
https://doi.org/10.1002/cncr.20332
El Khashab M, Gargan L, Margraf L, Koral K, Nejat F, Swift D, et al. Predictors of tumor progression among children with gangliogliomas. Clinical article. J Neurosurg Pediatr. 2009;3:461-6.
https://doi.org/10.3171/2009.2.PEDS0861
Dudley RW, Torok MR, Gallegos DR, Mulcahy-Levy JM, Hoffman LM, Liu AK, et al. Hoffman LM. Pediatric low-grade ganglioglioma: epidemiology, treatments, and outcome analysis on 348 children from the surveillance, epidemiology, and end results database. Neurosurgery. 2015;76:313-20
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