Español Incidence of acute graft-versus-host disease in the patients with matched sibling donor hematopoietic stem cell transplant at a medical center
DOI:
https://doi.org/10.35509/01239015.893Keywords:
Graft vs host disease, hematopoietic stem cell transplantation, donor selectionAbstract
Objective: Acute graft-versus-host disease (aGVHD) is one of the complications of allogeneic hematopoietic stem cell transplantation (AHSCT). This study aims to describe the incidence and prognostic factors of aGVHD in adult patients receiving matched sibling donor AHSCT.
Methods: Between 2015 and 2018, a retrospective cohort study was carried out with patients undergoing AHSCT from matched sibling donor at a medical center in the city of Bogotá, Colombia.
Results: The incidence of aGVHD was 59.79 % (n=58). In the univariate and multivariate Cox regression analysis, the female sex of the donor was a prognostic factor (p=0.04 and p=0.004, respectively). Likewise, myeloablative conditioning (HR=2.43, p=0.0230), prophylaxis other than cyclophosphamide (HR=2.48, p=0.0290), and donor age (HR=1.02, p=0.0200) were evidenced as independent predictors of aGVHD. Regarding relapse-free survival after one year, the difference between patients with aGVHD and without aGVHD was 90.51% and 63.94%, respectively (p=0.0014). Similarly, it was found that patients with aGVHD GI-II had an overall survival of 85.71%, while patients with GVHD GIII-IV had a lower rate of 63.64% (ꭓ2=0.0633).
Conclusions: The incidence of aGVHD in our study is similar to those found in previous studies. The development of aGVHD decreased the risk of relapse and impacted the one-year progression-free survival, but overall survival improvement was limited to patients with aGVHD GI-II.
Author Biographies
Angie Paola Guarín-Castañeda, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Gloria Elena Mora-Figueroa, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Enrique Pedraza-Mesa, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Javier Leonardo Figueroa-Camacho, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Óscar Javier Peña-Ardila, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
María José López-Mora, Infectología, Clínica de Marly, Bogotá, D. C., Colombia.
2. Infectología, Clínica de Marly, Bogotá, D. C., Colombia.
Paula Lucía Pinzón-Leal, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
César Augusto Lamadrid-Sastre, Medicina General, Clínica de Marly, Bogotá, D. C., Colombia.
3. Medicina General, Clínica de Marly, Bogotá, D. C., Colombia.
Gustavo Adolfo López-Castañeda, Medicina General, Clínica de Marly, Bogotá, D. C., Colombia.
3. Medicina General, Clínica de Marly, Bogotá, D. C., Colombia.
Francy Licet Villamizar-Gómez, Epidemiología Clínica, Clínica de Marly, Bogotá, D. C., Colombia
4. Epidemiología Clínica, Clínica de Marly, Bogotá, D. C., Colombia
Carlos Fernando Gómez-Calcetero, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Mauricio Efraín Gómez-Ortiz, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Sergio Felipe Ardila, Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
1. Hematología, Clínica de Marly, Bogotá, D. C., Colombia.
Herman Esguerra, Oncología, Radioterapia, Clínica de Marly, Bogotá, D. C., Colombia
5. Oncología, Radioterapia, Clínica de Marly, Bogotá, D. C., Colombia
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