Implementation of the Bethesda system for cytology reporting of thyroid fi ne needle aspirates with histological follow-up: experience in a cancer treatment center
Keywords:
Thyroid Gland, Fine-Needle Biopsy, Terminology, PathologyAbstract
Objective: To determine the frequency of the final histological diagnosis in the follow-up of cytology results of thyroid fine needle aspirates implemented using the Bethesda system (BS).
Methods: A cross-sectional study was conducted comparing the cytology results of thyroid fine needle aspirates implemented with the BS, and the final histopathology result in patients with thyroid gland lesions, who were seen in the Colombia National Cancerology Institute during the years 2010 to 2012.
Results: A review was made of the cytopathology and histopathology reports of 104 patients with thyroid nodules. The mean age of the patients was 51.9 years. The results of the cytopathology by BS categories were: 37.5% category V, 30.8% category VI, 15.4% category IV, 6.7% categories I and II, and 2.9% category III. Papillary carcinoma was the most frequent histopathology diagnosis of all the cases, with 76%, followed by goiter with 6.7%. In the comparative analysis, the cytology categories IV, V and VI, 89.8% of the cases had a malignant lesion in the final histology report, and 77% of those of category II (benign) had the same result in the final histopathology diagnosis.
Conclusions: The cytology of thyroid fine needle aspirates interpreted using the BS in the National Institute of Cancerology is of high diagnostic quality in the detection of thyroid malignancy when compared with the final histopathology diagnosis.
Author Biographies
Alfredo Romero Rojas, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá, Colombia
Mario Alexander Melo Uribe, Universidad de La Sabana
Grupo de Patología Quirúrgica, Universidad de La Sabana, Chía, Cundinamarca, Colombia
References
Rojeski M, Gharib H. Nodular thyroid disease. Evaluation and management. N Engl J Med. 1985;313:428-36.
https://doi.org/10.1056/NEJM198508153130707
Bose S, Walts A. Thyroid Fine Need le Aspirate :A Post-Bethesda Update. Adv Anat Pathol. 2012;19:160-9.
https://doi.org/10.1097/PAP.0b013e3182534610
SEER Stat Fact Sheets: Thyroid. 2012; Disponible en: http://seer.cancer.gov/statfacts/html/thyro.html
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer; Coper D, Doherty G, Haugen B, KloosRT, Lee SL, Mandel SJ, et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167-214.
https://doi.org/10.1089/thy.2009.0110
Cibas E, Ali S. The Bethesda System for reporting thyroid cytopathology. Am J Clin Pathol. 2009;132:658-65.
https://doi.org/10.1309/AJCPPHLWMI3JV4LA
Bryan K, Richmond B, O'brien, Mangano W, Thompson S, Kemper S. The impact of implementation of the Bethesda System for reporting thyroid cytopathology on the surgical treatment of thyroid nodules. Am Surgeon. 2012;78:706-10.
DeLellis R, Lloyd R, Heitz P, Eng C. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs. Lión: IARC Press; 2004.
Garavito G, Llamas A, Cadena E, De Los Reyes A, Hurtado G, Rojas L, et al. Manejo multidisciplinario del cáncer diferenciado de tiroides en el Instituto Nacional de Cancerología. Rev Colomb Cancerol. 2010;14:65-77.
https://doi.org/10.1016/S0123-9015(10)70100-1
Chala A, Franco H, Aguilar C, Cardona J. Estudio descriptivo de doce años de cáncer de tiroides, Manizales, Colombia. Rev Colomb Cir. 2010;25:276-89.
Ozluk Y, Pehlivan E, Gulluoglu MG, Poyanli A, Salmaslioglu A, Colak N, et al. The use of the Bethesda terminology in thyroid fine-needle aspiration results in a lower rate of surgery for nonmalignant nodules: a report from a reference center in Turkey. Int J Surg Pathol. 2011;19:761-71.
https://doi.org/10.1177/1066896911415667
Crowe A, Linder A, Hameed O, Salih C, Roberson J, Gidley J ,et al. The impact of implementation of the Bethesda System for Reporting Thyroid Cytopathology on the quality of reporting, 'risk' of malignancy, surgical rate, and rate of frozen sections requested for thyroid lesions. Cancer Cytopathol. 2011;119: 315-21.
https://doi.org/10.1002/cncy.20174
González C, Rojas A. Cáncer de tiroides: correlación diagnóstica. Revista Facultad de Ciencias de la Salud Universidad del Cauca. 2004;6.
Theoharis C, Schofield K, Hammers L, Udelsman R, Chhieng DC. The Bethesda thyroid fine needle aspiration classification system: year 1 at an academic institution. Thyroid. 2009;19: 1215-23.
https://doi.org/10.1089/thy.2009.0155
Rabaglia J, Kabbani W, Wallace L, Holt S, Watumull L, Pruitt J, et al. Effect of the Bethesda system for reporting thyroid cytopathology on thyroidectomy rates and malignancy risk in cytologically indeterminate lesions. Surgery. 2010;148:1267-73.
https://doi.org/10.1016/j.surg.2010.09.017
Yang J, Schnadig V, Logrono R, Wasserman PG. Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer. 2007;111:306-15.
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